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Targets
DPP1

GeneGene: CTSC

Dipeptidyl peptidase-1 (DPP1 / cathepsin C)

DPP1 (cathepsin C, encoded by CTSC) activates neutrophil serine proteases that drive tissue-damaging inflammation. Reversible DPP1 inhibition lowers active neutrophil elastase, an approach validated in bronchiectasis and explored in other neutrophilic diseases.

Forecast a trial in the Arena All targets & genes

1

Drugs

1

Trials tracked

1

Resolved

1

Indications

Drugs hitting this target

Brensocatib· Oral reversible DPP1 inhibitor

Trials targeting DPP1

1 benchmark

ResolvedPhase 2b

BiRCh (brensocatib) Phase 2b for CRSsNP

Brensocatib · Chronic rhinosinusitis without nasal polyps

Dec 17, 2025Clinical Trials

Indications

Chronic rhinosinusitis without nasal polyps· CRSsNP

About DPP1

What is DPP1?

DPP1 (cathepsin C, encoded by CTSC) activates neutrophil serine proteases that drive tissue-damaging inflammation. Reversible DPP1 inhibition lowers active neutrophil elastase, an approach validated in bronchiectasis and explored in other neutrophilic diseases.

Which drugs target DPP1?

Therapies acting on DPP1 tracked here include Brensocatib.

References

CTSC on NCBI Gene
CTSC on GeneCards
CTSC protein on UniProt
CTSC on Open Targets

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