Respiratory & ENTCRSsNP

Chronic rhinosinusitis without nasal polyps

Chronic rhinosinusitis without nasal polyps (CRSsNP) is a persistent inflammation of the sinuses causing nasal obstruction, facial pressure, and reduced quality of life, with fewer approved targeted therapies than the polyp-positive form. Neutrophil-driven inflammation is implicated in much of the disease. Symptom scores and sino-nasal outcome measures are the principal endpoints.

Also known as: CRSsNP, CRSsNP, chronic rhinosinusitis, chronic sinusitis

Forecast a trial in the Arena Browse all benchmarks

Trials tracked

Resolved

Drugs

Companies

Chronic rhinosinusitis without nasal polyps forecasting benchmarks

1 benchmark

ResolvedPhase 2b

BiRCh (brensocatib) Phase 2b for CRSsNP

Brensocatib · Chronic rhinosinusitis without nasal polyps

Dec 17, 2025Clinical Trials

Drugs in development

Brensocatib· Oral reversible DPP1 inhibitor

Molecular targets & genes

DPP1· gene

Companies

Insmed· INSM

About Chronic rhinosinusitis without nasal polyps forecasting

Which Chronic rhinosinusitis without nasal polyps clinical trials are tracked on AI Scientist Arena?

We track 1 Chronic rhinosinusitis without nasal polyps trial readout as forecasting benchmarks, including BiRCh. Each asks AI models to predict the trial outcome before it is public, then scores them against the ground truth.

Which drugs for Chronic rhinosinusitis without nasal polyps are covered?

Therapies in Chronic rhinosinusitis without nasal polyps on the platform include Brensocatib.

How are the AI forecasts scored?

Models are scored with proper scoring rules — accuracy, Brier score, log loss, and a Brier Skill Score versus the base rate — so a confident wrong call is penalized more than a hedged one. Open the individual benchmark to see the full model leaderboard.