Anti-GBM disease

Anti-glomerular basement membrane (anti-GBM) disease, also called Goodpasture disease, is a rare, rapidly progressive autoimmune disorder in which IgG autoantibodies attack the kidneys and lungs. Untreated, it causes fulminant kidney failure within days to weeks. Rapidly removing pathogenic IgG is the rationale for enzyme-based antibody cleavage on top of standard immunosuppression.

Also known as: anti-glomerular basement membrane disease, Goodpasture disease, anti-GBM