Tyrosine kinase 2 (TYK2)

TYK2 is a JAK-family kinase that transmits signaling from type-I interferon and select interleukins (IL-12, IL-23). Selective TYK2 inhibition dampens these inflammatory pathways while sparing the broader JAK1/2/3 signaling, an approach pursued across autoimmune diseases such as dermatomyositis and lupus.