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The gonadotropin-releasing hormone receptor governs the release of LH and FSH. Sustained GnRH-agonist stimulation paradoxically desensitizes the receptor and suppresses sex-hormone production, the basis for halting central precocious puberty.
The gonadotropin-releasing hormone receptor governs the release of LH and FSH. Sustained GnRH-agonist stimulation paradoxically desensitizes the receptor and suppresses sex-hormone production, the basis for halting central precocious puberty.
Therapies acting on GnRH-R tracked here include FP-001 (leuprolide mesylate).